Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Background More than 200 years after James Parkinsondescribed a clinical syndrome
based on his astute observations, Parkinson's disease (PD) has evolved into a complex …

Parkinson's disease (PD) is defined as a complex disorder with multifactorial pathogenesis,
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …

LRRK2 variants are implicated in both familial and sporadic PD. LRRK2‐PD has a generally
benign clinical presentation and variable pathology, with inconsistent presence of Lewy …

Background Aging is the strongest risk factor for Parkinson's disease (PD), which is a
clinically heterogeneous movement disorder with highly variable age at onset. DNA …

Parkinson's disease (PD) is a neurodegenerative disease with unknown cause in the
majority of patients, who are therefore considered “idiopathic”(IPD). PD predominantly …

After fifteen years of genome-wide association studies (GWAS) in Parkinson's disease (PD),
what have we learned? Addressing this question will help catalogue the progress made …

Abstract Purpose of Review Genetic variants in GBA1 and LRRK2 genes are the commonest
genetic risk factor for Parkinson disease (PD); however, the preclinical profile of GBA1 and …

Summary α-Synuclein (α-syn) is important in synucleinopathies such as Parkinson's disease
(PD). While genome-wide association studies (GWASs) of synucleinopathies have identified …