Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid
detection and quantification of resistance, combined with antimicrobial stewardship, are key …

Covering: 2008 up to 2019 The forces of biochemical adaptive evolution operate at the level
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …

De novo gene emergence provides a route for new proteins to be formed from previously
non-coding DNA. Proteins born in this way are considered random sequences and typically …

Abstract “De novo” genes evolve from previously non-genic DNA. This strikes many of us as
remarkable, because it seems extraordinarily unlikely that random sequence would produce …

Recent evidence demonstrates that novel protein-coding genes can arise de novo from non-
genic loci. This evolutionary innovation is thought to be facilitated by the pervasive …

Antibiotic resistance is a rapidly increasing medical problem that severely limits the success
of antibiotic treatments, and the identification of resistance determinants is key for …

The exponential growth of aquaculture over the past 30 years has been accompanied by a
parallel increase in the use of antimicrobials. This widespread use has had negative effects …

Harder, better, faster, stronger: Colistin resistance mechanisms in Escherichia coli | PLOS
Genetics Skip to main content Advertisement PLOS Genetics Browse Current Issue Journal …

Increasing numbers of small proteins with diverse physiological roles are being identified
and characterized in both prokaryotic and eukaryotic systems, but the origins and evolution …

Chromosomally encoded toxin-antitoxin systems have been increasingly identified and
characterized across bacterial species over the past two decades. Overproduction of the …