The separation, identification and quantification of constituents in complex plant extracts
always has been, and most likely will be, a challenging task. Nevertheless, today a …

Lactate racemase (LarA) of Lactobacillus plantarum contains a novel organometallic
cofactor with nickel coordinated to a covalently tethered pincer ligand, pyridinium-3 …

Gentiopicrin, the main component of the famous Chinese patent medicine Long Dan Xie
Gan Wan, has the characteristics of fast absorption in vivo and low bioavailability. Intestinal …

A series of 26 novel derivatives have been synthesized through structural modification of
gentiopicroside, a lead COX-2 inhibitor. And their in vivo and in vitro anti-inflammatory …

Objective To isolate high-purity gentiopicroside from the Chinese herbal Gentiana officinalis
and investigate its anti-inflammatory activity against iNOS and COX-2 targets. Methods The …

The use of phytochemicals and herbal medicines has accompanied human history.
Advances in modern biomedical sciences have allowed us to investigate the functional …

Extracts of Gentianaceae herbs have been widely used as food additives, teas, or medicinal
remedies for various human diseases and disorders. Iridoids, secoiridoids, and analogs …

Gentiopicroside is a natural secoiridoid glycoside that may require metabolic activation to
exert pharmacological effects. In this study, two active metabolites of gentiopicroside (M1 …

Background: Inflammation is a major factor in the development of acute renal damage and
the Toll-like receptor 4 (TLR4) signaling pathway is a major contributor to inflammation in the …

Medicinal Plants in Asia for Metabolic Syndrome: Natural Products and Molecular Basis
offers an in-depth view into the metabolic syndrome pharmacology of natural products with …