NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Neddylation is one type of protein post‐translational modification by conjugating a ubiquitin‐
like protein neural precursor cell‐expressed developmentally downregulated protein 8 to …

Abstract Mps one binder 2 (MOB2) regulates the NDR kinase family, however, whether and
how it is implicated in cancer remain unknown. Here we show that MOB2 functions as a …

Hepatocarcinogenesis is a complex multistep biological process involving genetic and
epigenetic alterations that are accompanied by activation of oncoproteins and inactivation of …

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is
dynamically regulated through distinct protein complexes that methylate, demethylate …

Hepatocellular carcinoma (HCC) has poor prognosis and is usually diagnosed only at an
advanced stage. Identification of novel biomarkers is critical to early diagnosis and better …

Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-
dependent lipid peroxidation. Cancer cells differ in their sensitivity to ferroptosis. Here we …

Purpose Overactivated neddylation is considered to be a common event in cancer. Long
non-coding RNAs (lncRNAs) can regulate cancer development by mediating post …

Emerging studies suggest that microRNAs (miRNAs) play multiple roles in cancer
malignancy, including proliferation and acquisition of metastatic potential. Differentially …

Ajuba dysregulation has been reported in several human cancers. However, its expression
patterns and biological roles in human gastric cancers have not yet been characterized. In …