Lost in translation: the valley of death across preclinical and clinical divide–identification of problems and overcoming obstacles
AA Seyhan - Translational Medicine Communications, 2019 - Springer
A rift that has opened up between basic research (bench) and clinical research and patients
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …
Use of zebrafish in drug discovery toxicology
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …
health and money. The drug discovery industry attempts to minimize those events with …
The resolution of inflammation: Principles and challenges
SE Headland, LV Norling - Seminars in immunology, 2015 - Elsevier
The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …
Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …
emergence of systems approaches in biology promises new therapies, faster and cheaper …
In vivo acoustic manipulation of microparticles in zebrafish embryos
In vivo micromanipulation using ultrasound is an exciting technology with promises for
cancer research, brain research, vasculature biology, diseases, and treatment development …
cancer research, brain research, vasculature biology, diseases, and treatment development …
[HTML][HTML] Organ-on-a-chip meets artificial intelligence in drug evaluation
S Deng, C Li, J Cao, Z Cui, J Du, Z Fu, H Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …
industry. However, animal welfare protection and other shortcomings of traditional drug …
Zebrafish embryos as an alternative to animal experiments—A commentary on the definition of the onset of protected life stages in animal welfare regulations
Worldwide, the zebrafish has become a popular model for biomedical research and (eco)
toxicology. Particularly the use of embryos is receiving increasing attention, since they are …
toxicology. Particularly the use of embryos is receiving increasing attention, since they are …
Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish
The zebrafish (Danio rerio) is emerging as a promising model organism for experimental
studies of stress and anxiety. Here we further validate zebrafish models of stress by …
studies of stress and anxiety. Here we further validate zebrafish models of stress by …
Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells
Human endothelial cells (ECs) and pericytes are of great interest for research on vascular
development and disease, as well as for future therapy. This protocol describes the efficient …
development and disease, as well as for future therapy. This protocol describes the efficient …
Measuring behavioral and endocrine responses to novelty stress in adult zebrafish
Several behavioral assays are currently used for high-throughput neurophenotyping and
screening of genetic mutations and psychotropic drugs in zebrafish (Danio rerio). In this …
screening of genetic mutations and psychotropic drugs in zebrafish (Danio rerio). In this …