We recently reported evidence of Alzheimer's disease (AD)-linked genetic variation within
the mucin 6 (MUC6) gene on chromosome 11p, nearby the adaptor-related protein complex …

Central nerve terminals contain a small number of synaptic vesicles (SVs) that must sustain
the fidelity of neurotransmission across a wide range of stimulation intensities. For this to be …

Activity-dependent bulk endocytosis (ADBE) is the dominant mode of synaptic vesicle
endocytosis during high-frequency stimulation, suggesting it should play key roles in …

Toxoplasma gondii possesses a highly polarized secretory system, which efficiently
assembles de novo micronemes and rhoptries during parasite replication. These apical …

We found evidence of late-onset Alzheimer disease (LOAD)-associated genetic
polymorphism within an exon of Mucin 6 (MUC6) and immediately downstream from another …

Aging results in increased neuromuscular transmission failure and denervation of the
diaphragm muscle, as well as decreased force generation across a range of motor …

Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis
depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters …

The AP1/σ1B knockout causes impaired synaptic vesicle recycling and enhanced protein
sorting into endosomes, leading to severe intellectual disability. These disturbances in …

The σ1 subunit of the AP-1 clathrin-coated-vesicle adaptor-protein complex is expressed as
three isoforms. Tissues express σ1A and one of the σ1B and σ1C isoforms. Brain is the …

Abstract AP2 forms AP2 CCV with clathrin and over 60 additional coat proteins. Due to this
complexity, we have a limited understanding of CCV life cycle regulation. Synapses contain …