Pathogenesis of pneumonia and acute lung injury
ME Long, RK Mallampalli, JC Horowitz - Clinical Science, 2022 - portlandpress.com
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …
and critical care healthcare professionals, and these challenges have recently garnered …
Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
[HTML][HTML] Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites
Resident memory B (BRM) cells develop and persist in the lungs of influenza-infected mice
and humans; however, their contribution to recall responses has not been defined. Here, we …
and humans; however, their contribution to recall responses has not been defined. Here, we …
Tissue-resident B cells orchestrate macrophage polarisation and function
B cells play a central role in humoral immunity but also have antibody-independent
functions. Studies to date have focused on B cells in blood and secondary lymphoid organs …
functions. Studies to date have focused on B cells in blood and secondary lymphoid organs …
Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles
Recent studies have established that memory B cells, largely thought to be circulatory in the
blood, can take up long-term residency in inflamed tissues, analogous to widely described …
blood, can take up long-term residency in inflamed tissues, analogous to widely described …
Resident memory B cells in barrier tissues
CM Lee, JE Oh - Frontiers in Immunology, 2022 - frontiersin.org
Epithelial barriers, which include the gastrointestinal, respiratory, and genitourinary mucosa,
compose the body's front line of defense. Since barrier tissues are persistently exposed to …
compose the body's front line of defense. Since barrier tissues are persistently exposed to …
Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection
Abstract The SARS‐CoV‐2 Delta (B. 1.617. 2) variant is capable of infecting vaccinated
persons. An open question remains as to whether deficiencies in specific vaccine‐elicited …
persons. An open question remains as to whether deficiencies in specific vaccine‐elicited …
The multifaceted roles of B cells in the thymus: from immune tolerance to autoimmunity
The thymus is home to a significant number of resident B cells which possess several
unique characteristics regarding their origin, phenotype and function. Evidence shows that …
unique characteristics regarding their origin, phenotype and function. Evidence shows that …
[HTML][HTML] A single-cell lung atlas of complement genes identifies the mesothelium and epithelium as prominent sources of extrahepatic complement proteins
N Chaudhary, A Jayaraman, C Reinhardt… - Mucosal …, 2022 - Elsevier
To understand functional duality of the complement system in host defense and lung injury,
a more comprehensive view of its localized production in the lung, and the impact of age on …
a more comprehensive view of its localized production in the lung, and the impact of age on …
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa
B Vesin, J Lopez, A Noirat, P Authié, I Fert… - Molecular Therapy, 2022 - cell.com
As the coronavirus disease 2019 (COVID-19) pandemic continues and new severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern emerge, the adaptive …
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern emerge, the adaptive …