A new perspective on lysogeny: prophages as active regulatory switches of bacteria

R Feiner, T Argov, L Rabinovich, N Sigal… - Nature Reviews …, 2015 - nature.com
Unlike lytic phages, temperate phages that enter lysogeny maintain a long-term association
with their bacterial host. In this context, mutually beneficial interactions can evolve that …

[HTML][HTML] Bacteriophage lambda: Early pioneer and still relevant

SR Casjens, RW Hendrix - Virology, 2015 - Elsevier
Molecular genetic research on bacteriophage lambda carried out during its golden age from
the mid-1950s to mid-1980s was critically important in the attainment of our current …

Cryptic prophages help bacteria cope with adverse environments

X Wang, Y Kim, Q Ma, SH Hong, K Pokusaeva… - Nature …, 2010 - nature.com
Phages are the most abundant entity in the biosphere and outnumber bacteria by a factor of
10. Phage DNA may also constitute 20% of bacterial genomes; however, its role is ill …

Impact of spontaneous prophage induction on the fitness of bacterial populations and host-microbe interactions

AM Nanda, K Thormann, J Frunzke - Journal of bacteriology, 2015 - Am Soc Microbiol
Bacteriophages and genetic elements, such as prophage-like elements, pathogenicity
islands, and phage morons, make up a considerable amount of bacterial genomes. Their …

Switches in bacteriophage lambda development

AB Oppenheim, O Kobiler, J Stavans… - Annu. Rev …, 2005 - annualreviews.org
The lysis-lysogeny decision of bacteriophage lambda (λ) is a paradigm for developmental
genetic networks. There are three key features, which characterize the network. First, after …

Bacteriophages of Shiga Toxin-Producing Escherichia coli and Their Contribution to Pathogenicity

L Rodríguez-Rubio, N Haarmann, M Schwidder… - Pathogens, 2021 - mdpi.com
Shiga toxins (Stx) of Shiga toxin-producing Escherichia coli (STEC) are generally encoded
in the genome of lambdoid bacteriophages, which spend the most time of their life cycle …

Phage therapy: what have we learned?

A Górski, R Międzybrodzki, M Łobocka… - Viruses, 2018 - mdpi.com
In this article we explain how current events in the field of phage therapy may positively
influence its future development. We discuss the shift in position of the authorities …

The players in a mutualistic symbiosis: insects, bacteria, viruses, and virulence genes

NA Moran, PH Degnan, SR Santos… - Proceedings of the …, 2005 - National Acad Sciences
Aphids maintain mutualistic symbioses involving consortia of coinherited organisms. All
possess a primary endosymbiont, Buchnera, which compensates for dietary deficiencies; …

Shiga toxins and stx phages: highly diverse entities

A Krüger, PMA Lucchesi - Microbiology, 2015 - microbiologyresearch.org
Shiga toxins are the main virulence factors of a group of Escherichia coli strains [Shiga toxin-
producing E. coli (STEC)] that cause severe human diseases, such as haemorrhagic colitis …

Single-molecule imaging of LexA degradation in Escherichia coli elucidates regulatory mechanisms and heterogeneity of the SOS response

EC Jones, S Uphoff - Nature microbiology, 2021 - nature.com
The bacterial SOS response represents a paradigm of gene networks controlled by a master
transcriptional regulator. Self-cleavage of the SOS repressor LexA induces a wide range of …