Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population
of the immune system. They play a pivotal role in the establishment of the tumor …

Purpose: High levels of circulating myeloid-derived suppressor cells (MDSCs) in various
cancer types, including melanoma, were shown to correlate with poor survival. We …

Prostate cancer (PC) is the second most often diagnosed malignancy in men and one of the
major causes of cancer death worldwide. Despite genetic predispositions, environmental …

Ipilimumab has revolutionized malignant melanoma therapy, but a better understanding of
the mechanisms behind treatment response and adverse effects is needed. In this work, the …

A recent study indicated that Lectin‐type oxidized LDL receptor‐1 (LOX‐1) was a distinct
surface marker for human polymorphisms myeloid‐derived suppressor cells (PMN‐MDSC) …

Pathological conditions including cancers lead to accumulation of a morphological mixture
of highly immunosuppressive cells termed as myeloid-derived suppressor cells (MDSC) …

Background Triple-negative breast cancer (TNBC) is characterised by high pathological
complete response to neoadjuvant chemotherapy (NAC). However, refractory and poor NAC …

Blockade of the PD-1 receptor has revolutionized the treatment of metastatic melanoma, with
significant increases in overall survival (OS) and a dramatic improvement in patient quality of …

Tumor dormancy is a stage in which residual cancer cells remain inactive, but regrowth of
dormant cancer cells contributes to recurrence. The complex ecosystem in cancer that …

Background Myeloid-derived suppressor cells (MDSC) have been found to play an
important role in limiting immune responses in cancer. Higher circulating MDSC levels have …