In this review, we describe the developments in the field of naphthalene diimides (NDIs)
from 2016 to the presentday. NDIs are shown to be an increasingly interesting class of …

Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Besides the well-known DNA double-helix, non-canonical nucleic acid structures regulate
crucial biological activities. Among these oddities, guanine-rich DNA sequences can form …

Guanine-rich nucleic acid sequences can fold into four-stranded G-quadruplex (G4)
structures. Despite growing evidence for their biological significance, considerable work still …

G-quadruplexes are four-stranded nucleic acids structures that can form in guanine-rich
sequences. Following the observation that G-quadruplexes are particularly abundant in …

Guanidine DNA quadruplex (G4-DNA) structures convey a distinctive layer of epigenetic
information that is critical for regulating key biological activities and processes as …

Several G-quadruplex nucleic acid (G4s) ligands have been developed seeking target
selectivity in the past decade. Naphthalene diimide (NDI)-based compounds are particularly …

Naphthalene diimides showed significant anticancer activity in animal models, with
therapeutic potential related to their ability to strongly interact with G-quadruplexes …

Abstract DNA G‐quadruplexes (G4s) are key structures for the development of targeted
anticancer therapies. In this context, ligands selectively interacting with G4s can represent …

Target selectivity is one of the main challenges in the search for small molecules able to act
as effective and non-toxic anticancer and/or antiviral drugs. To achieve this goal, handy …