A journey through the lectin pathway of complement—MBL and beyond
Summary Mannose‐binding lectin (MBL), collectin‐10, collectin‐11, and the ficolins (ficolin‐
1, ficolin‐2, and ficolin‐3) are soluble pattern recognition molecules in the lectin complement …
1, ficolin‐2, and ficolin‐3) are soluble pattern recognition molecules in the lectin complement …
Mannose-binding lectin: the pluripotent molecule of the innate immune system
MW Turner - Immunology today, 1996 - cell.com
Mannose-binding lectin (MBL) is a versatile macromolecule, embodying functional
characteristics of IgM, IgG and C1q. It might be particularly important in the early stages of a …
characteristics of IgM, IgG and C1q. It might be particularly important in the early stages of a …
Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition
O Neth, DL Jack, AW Dodds, H Holzel… - Infection and …, 2000 - Am Soc Microbiol
Mannose-binding lectin (MBL) is a collagenous serum lectin believed to be of importance in
innate immunity. Genetically determined low levels of the protein are known to predispose to …
innate immunity. Genetically determined low levels of the protein are known to predispose to …
Mannose-binding lectin and its genetic variants
Mannose-binding lectin (MBL) is a collagen-like serum protein that mediates activation of
the complement system and is of importance for host defence. Common variant alleles …
the complement system and is of importance for host defence. Common variant alleles …
A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein
HO Madsen, P Garred, JAL Kurtzhals, LU Lamm… - Immunogenetics, 1994 - Springer
Human mannan-binding protein (MBP) is a serum lectin participating in the innate immune
defence. Low MBP concentrations are explained by the dominant action of a point mutation …
defence. Low MBP concentrations are explained by the dominant action of a point mutation …
Mannose-binding lectin deficiency—revisited
P Garred, F Larsen, HO Madsen, C Koch - Molecular immunology, 2003 - Elsevier
There is an emerging interest for mannose-binding lectin (MBL) due to its role in innate
immunity. In this survey we present a mixture of old and new data describing the effect MBL …
immunity. In this survey we present a mixture of old and new data describing the effect MBL …
Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America
HO Madsen, ML Satz, B Hogh, A Svejgaard… - The Journal of …, 1998 - journals.aai.org
Previous studies have shown that three point mutations in exon 1 and a particular promoter
haplotype of the mannan-binding lectin (MBL) gene lead to a dramatic decrease in the …
haplotype of the mannan-binding lectin (MBL) gene lead to a dramatic decrease in the …
[HTML][HTML] Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis
P Garred, T Pressler, HO Madsen… - The Journal of …, 1999 - Am Soc Clin Investig
Mannose-binding lectin (MBL) is a key factor in innate immunity, and lung infections are the
leading cause of morbidity and mortality in cystic fibrosis (CF). Accordingly, we investigated …
leading cause of morbidity and mortality in cystic fibrosis (CF). Accordingly, we investigated …
The mannan-binding lectin pathway of complement activation: biology and disease association
SV Petersen, S Thiel, JC Jensenius - Molecular immunology, 2001 - Elsevier
Mannan-binding lectin (MBL) is a plasma protein found in association with several serine
proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures …
proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures …
Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin
P Garred, HO Madsen, U Balslev, BO Hofmann… - The Lancet, 1997 - thelancet.com
Background Low serum concentrations of mannose-binding lectin (MBL) are associated with
increased susceptibility to recurrent infection. Three variant alleles in the MBL gene (B, C …
increased susceptibility to recurrent infection. Three variant alleles in the MBL gene (B, C …