A journey through the lectin pathway of complement—MBL and beyond

P Garred, N Genster, K Pilely… - Immunological …, 2016 - Wiley Online Library
Summary Mannose‐binding lectin (MBL), collectin‐10, collectin‐11, and the ficolins (ficolin‐
1, ficolin‐2, and ficolin‐3) are soluble pattern recognition molecules in the lectin complement …

Mannose-binding lectin: the pluripotent molecule of the innate immune system

MW Turner - Immunology today, 1996 - cell.com
Mannose-binding lectin (MBL) is a versatile macromolecule, embodying functional
characteristics of IgM, IgG and C1q. It might be particularly important in the early stages of a …

Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition

O Neth, DL Jack, AW Dodds, H Holzel… - Infection and …, 2000 - Am Soc Microbiol
Mannose-binding lectin (MBL) is a collagenous serum lectin believed to be of importance in
innate immunity. Genetically determined low levels of the protein are known to predispose to …

Mannose-binding lectin and its genetic variants

P Garred, F Larsen, J Seyfarth, R Fujita… - Genes & Immunity, 2006 - nature.com
Mannose-binding lectin (MBL) is a collagen-like serum protein that mediates activation of
the complement system and is of importance for host defence. Common variant alleles …

A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein

HO Madsen, P Garred, JAL Kurtzhals, LU Lamm… - Immunogenetics, 1994 - Springer
Human mannan-binding protein (MBP) is a serum lectin participating in the innate immune
defence. Low MBP concentrations are explained by the dominant action of a point mutation …

Mannose-binding lectin deficiency—revisited

P Garred, F Larsen, HO Madsen, C Koch - Molecular immunology, 2003 - Elsevier
There is an emerging interest for mannose-binding lectin (MBL) due to its role in innate
immunity. In this survey we present a mixture of old and new data describing the effect MBL …

Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America

HO Madsen, ML Satz, B Hogh, A Svejgaard… - The Journal of …, 1998 - journals.aai.org
Previous studies have shown that three point mutations in exon 1 and a particular promoter
haplotype of the mannan-binding lectin (MBL) gene lead to a dramatic decrease in the …

[HTML][HTML] Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis

P Garred, T Pressler, HO Madsen… - The Journal of …, 1999 - Am Soc Clin Investig
Mannose-binding lectin (MBL) is a key factor in innate immunity, and lung infections are the
leading cause of morbidity and mortality in cystic fibrosis (CF). Accordingly, we investigated …

The mannan-binding lectin pathway of complement activation: biology and disease association

SV Petersen, S Thiel, JC Jensenius - Molecular immunology, 2001 - Elsevier
Mannan-binding lectin (MBL) is a plasma protein found in association with several serine
proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures …

Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin

P Garred, HO Madsen, U Balslev, BO Hofmann… - The Lancet, 1997 - thelancet.com
Background Low serum concentrations of mannose-binding lectin (MBL) are associated with
increased susceptibility to recurrent infection. Three variant alleles in the MBL gene (B, C …