Multi-scale computational modeling of spatial calcium handling from nanodomain to whole-heart: Overview and perspectives
Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …
excitation-contraction coupling. The calcium spark, the fundamental element of the …
Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes
KJ McCabe, P Rangamani - Journal of molecular and cellular cardiology, 2021 - Elsevier
The cAMP/PKA pathway is a fundamental regulator of excitation-contraction coupling in
cardiomyocytes. Activation of cAMP has a variety of downstream effects on cardiac function …
cardiomyocytes. Activation of cAMP has a variety of downstream effects on cardiac function …
Distinct functional roles of cardiac mitochondrial subpopulations revealed by a 3D simulation model
Experimental characterization of two cardiac mitochondrial subpopulations, namely,
subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM), has been …
subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM), has been …
Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses
E Polakova, EA Sobie - Cardiovascular research, 2013 - academic.oup.com
Compelling recent experimental results make clear that sub-cellular structures are altered in
ventricular myocytes during the development of heart failure, in both human samples and …
ventricular myocytes during the development of heart failure, in both human samples and …
Modeling Effects of L-Type Ca2+ Current and Na+-Ca2+ Exchanger on Ca2+ Trigger Flux in Rabbit Myocytes with Realistic T-Tubule Geometries
PM Kekenes-Huskey, Y Cheng, JE Hake… - Frontiers in …, 2012 - frontiersin.org
The transverse tubular system of rabbit ventricular myocytes consists of cell membrane
invaginations (t-tubules) that are essential for efficient cardiac excitation-contraction …
invaginations (t-tubules) that are essential for efficient cardiac excitation-contraction …
Mitochondrial colocalization with Ca2+ release sites is crucial to cardiac metabolism
In cardiomyocyte subcellular structures, colocalization of mitochondria with Ca 2+ release
sites is implicated in regulation of cardiac energetics by facilitating Ca 2+ influx into …
sites is implicated in regulation of cardiac energetics by facilitating Ca 2+ influx into …
[PDF][PDF] Calcium versus strontium handling by the heart muscle
M Hendrych, V Olejnickova, M Novakova - Gen. Physiol. Biophys, 2016 - researchgate.net
Calcium plays a crucial role in numerous processes in living systems, from both intracellular
and intercellular signalling to blood clotting. Calcium can be replaced by strontium in various …
and intercellular signalling to blood clotting. Calcium can be replaced by strontium in various …
Nanoscale, Voltage-Driven application of bioactive substances onto cells with organized topography
With scanning ion conductance microscopy (SICM), a noncontact scanning probe technique,
it is possible both to obtain information about the surface topography of live cells and to …
it is possible both to obtain information about the surface topography of live cells and to …
Computer simulation and modeling in pharmacokinetics and pharmacodynamics
Computer-based modeling and simulation is emerging as a useful tool to complement the
analysis and interpretation of biological data. The large volume, scale, and complexity of …
analysis and interpretation of biological data. The large volume, scale, and complexity of …
Automated generation of tissue-specific three-dimensional finite element meshes containing ellipsoidal cellular inclusions
Finite element analysis provides a means of describing cellular mechanics in tissue, which
can be useful in understanding and predicting physiological and pathological changes …
can be useful in understanding and predicting physiological and pathological changes …