The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

Q Li, S Mao, H Wang, X Ye - Marine Drugs, 2022 - mdpi.com
The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic
activity is one of the important inducements for bacteria to develop drug resistance. Bacteria …

Quorum Sensing Inhibitors to Quench P. aeruginosa Pathogenicity

M Duplantier, E Lohou, P Sonnet - Pharmaceuticals, 2021 - mdpi.com
The emergence and the dissemination of multidrug-resistant bacteria constitute a major
public health issue. Among incriminated Gram-negative bacteria, Pseudomonas aeruginosa …

Targeted and Enhanced Antimicrobial Inhibition of Mesoporous ZnO–Ag2O/Ag, ZnO–CuO, and ZnO–SnO2 Composite Nanoparticles

M Pandey, M Singh, K Wasnik, S Gupta, S Patra… - ACS …, 2021 - ACS Publications
In this work, mesoporous (pore size below 4 nm) composite nanoparticles of ZnO–Ag2O/Ag,
ZnO–CuO, and ZnO–SnO2 of size d≤ 10 nm (dia.) have been synthesized through the in …

Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease

A Matošević, DM Opsenica, M Spasić… - Chemico-biological …, 2023 - Elsevier
The most successful therapeutic strategy in the treatment of Alzheimer's disease (AD) is
directed toward increasing levels of the neurotransmitter acetylcholine (ACh) by inhibition of …

[HTML][HTML] Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR

S Grossman, F Soukarieh, W Richardson, R Liu… - European Journal of …, 2020 - Elsevier
Rising numbers of cases of multidrug-and extensively drug-resistant Pseudomonas
aeruginosa over recent years have created an urgent need for novel therapeutic …

Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance

RM Hassan, MS Abd El-Maksoud, IAY Ghannam… - European Journal of …, 2023 - Elsevier
The tremendous increase in the bacterial resistance to the available antibiotics is a serious
problem for the treatment of various infections. Biofilm formation in bacteria significantly …

Chemical probe of AHL modulators on quorum sensing in Gram-Negative Bacteria and as antiproliferative agents: A review

M Ampomah-Wireko, C Luo, Y Cao, H Wang… - European Journal of …, 2021 - Elsevier
Pathogenic bacteria use an intercellular chemical communication system called quorum
sensing (QS) to control the expression of cellular functions such as virulence factors, biofilm …

Copper (II) and zinc (II) complexes with the clinically used fluconazole: comparison of antifungal activity and therapeutic potential

NL Stevanović, I Aleksic, J Kljun, S Skaro Bogojevic… - Pharmaceuticals, 2020 - mdpi.com
Copper (II) and zinc (II) complexes with clinically used antifungal drug fluconazole
(fcz),{[CuCl2 (fcz) 2]. 5H2O} n, 1, and {[ZnCl2 (fcz) 2]· 2C2H5OH} n, 2, were prepared and …

Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa

S Sabir, T Das, R Kuppusamy, TT Yu, MDP Willcox… - Bioorganic …, 2023 - Elsevier
It is well established that the quorum sensing (QS) in Pseudomonas aeruginosa is primarily
responsible for the synthesis and the release of several virulence factors including …

Novel quinoline‐based derivatives as the PqsR inhibitor against Pseudomonas aeruginosa PAO1

XH Huang, MT She, YH Zhang, YF Liu… - Journal of applied …, 2022 - academic.oup.com
Aims The emerging of drug resistant Pseudomonas aeruginosa is a critical challenge and
renders an urgent action to discover innovative antimicrobial interventions. One of these …