Deep transcranial magnetic stimulation (TMS) is a technique of neuromodulation and
neurostimulation based on the principle of electromagnetic induction of an electric field in …

Tobacco use is strongly associated with a variety of psychiatric disorders. Smokers are more
likely than non-smokers to meet current criteria for mental health conditions, such as mood …

Objective To clarify the effects of smoking on the disposition of two commonly used
antipsychotics, olanzapine and clozapine, and to create standards to adjust the doses of …

During weak induction (from smoking and/or valproate co-prescription), clozapine ultrarapid
metabolizers (UMs) need very high daily doses to reach the minimum therapeutic …

Abstract Background and Objectives Although therapeutic drug monitoring of clozapine is
recommended, its optimisation is often adjusted only on the basis of dosage. The aim of this …

In 1989, clozapine (CLO) was marketed in the USA with limited pharmacokinetic studies. In
1994, Bertilsson et al. described CYP1A2 as explaining 70% of CLO metabolism [1]. While …

Evidences from studies on patients with overt cerebellar diseases as well as on healthy
individuals suggest a possible role for the cerebellum in cognition, mood and behaviour …

Objective: Clozapine is the only effective medication for treatment-resistant schizophrenia,
but its worldwide use is still limited because of its complex titration protocols. While the …

OBJECTIVE: The cingulate cortex is a functionally heterogeneous region involved in diverse
cognitive and emotional processes. It is a region of special interest to investigate the …

Objective The pharmacological self‐management of novel psychoactive substance (NPS)‐
induced psychopathological consequences represents a fast growing phenomenon. This is …