The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation

MK Harioudh, J Perez, L So, M Maheshwari, TS Ebert… - Immunity, 2024 - cell.com
An important property of the host innate immune response during microbial infection is its
ability to control the expression of antimicrobial effector proteins, but how this occurs post …

Specialized ribosomes in health and disease

SC Miller, CC MacDonald, MK Kellogg… - International Journal of …, 2023 - mdpi.com
Ribosomal heterogeneity exists within cells and between different cell types, at specific
developmental stages, and occurs in response to environmental stimuli. Mounting evidence …

Annelid adult cell type diversity and their pluripotent cellular origins

P Álvarez-Campos, H García-Castro, E Emili… - Nature …, 2024 - nature.com
Many annelids can regenerate missing body parts or reproduce asexually, generating all
cell types in adult stages. However, the putative adult stem cell populations involved in these …

K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution

AS Rahmanto, CJ Blum, C Scalera, JB Heidelberger… - Molecular Cell, 2023 - cell.com
Reactive aldehydes are produced by normal cellular metabolism or after alcohol
consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are …

[HTML][HTML] The lipid transporter HDLBP promotes hepatocellular carcinoma metastasis through BRAF-dependent epithelial-mesenchymal transition

J Yuan, T Lv, J Yang, Z Wu, L Yan, J Yang, Y Shi… - Cancer letters, 2022 - Elsevier
Tumor metastasis is a major cause of cancer mortality. However, little is known regarding the
regulation of abnormal cholesterol metabolism in hepatocellular carcinoma (HCC) …

[HTML][HTML] Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes

MK Hasan, LJ Brady - Journal of Structural Biology: X, 2024 - Elsevier
K-Homology domain (KH domain) proteins bind single-stranded nucleic acids, influence
protein–protein interactions of proteins that harbor them, and are found in all kingdoms of …

Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting

D Steinbrecht, I Minia, M Milek, J Meisig… - Molecular Systems …, 2024 - embopress.org
Eukaryotic mRNAs are transcribed, processed, translated, and degraded in different
subcellular compartments. Here, we measured mRNA flow rates between subcellular …

Translation of circular RNAs

G Margvelani, KAA Maquera, JR Welden… - Nucleic Acids …, 2025 - academic.oup.com
Circular RNAs (circRNAs) are covalently closed RNAs that are present in all eukaryotes
tested. Recent RNA sequencing (RNA-seq) analyses indicate that although generally less …

RAVER1 hinders lethal EMT and modulates miR/RISC activity by the control of alternative splicing

A Wedler, N Bley, M Glaß, S Müller… - Nucleic Acids …, 2024 - academic.oup.com
The RAVER1 protein serves as a co-factor in guiding the polypyrimidine tract-binding
protein (PTBP)-dependent control of alternative splicing (AS). Whether RAVER1 solely acts …

The high-density lipoprotein binding protein HDLBP is an unusual RNA-binding protein with multiple roles in cancer and disease

J Feicht, RP Jansen - RNA biology, 2024 - Taylor & Francis
The high-density lipoprotein binding protein (HDLBP) is the human member of an
evolutionarily conserved family of RNA-binding proteins, the vigilin protein family. These …