Fungi are opportunistic pathogens that infect immunocompromised patients and are
responsible for an estimated 1.5 million deaths every year. The antifungal innate immune …

Hundred-thousands of fungal species are present in our environment, including normal
colonizers that constitute part of the human microbiota. The homeostasis of host-fungus …

The lung is in continuous contact with a diverse array of infectious agents, foreign antigens,
and host-derived danger signals. To sample this expansive internal and external milieu …

Pneumocystis jirovecii is the opportunistic fungal organism that causes Pneumocystis
pneumonia (PCP) in humans. Similar to other opportunistic pathogens, Pneumocystis …

β-glucan is the most abundant polysaccharide in the cell wall of Pneumocystis jirovecii,
which has attracted extensive attention because of its unique immunobiological …

Pneumocystis pneumonia (PcP) in humans is caused by Pneumocystis jirovecii, which has
recently been reclassified as a fungus because its cell wall composition and nucleotide …

We found that absence of osteopontin (OPN) in immunocompromised Rag2−/− mice, which
lack T and B cells, made the mice extremely susceptible to an opportunistic fungus …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of
hematopoietic precursors with the ability to adversely affect host immunity. They have been …

Background: Clinical and laboratory evidence suggests that alcohol consumption prior to
burn injury leads to dysregulated immune function and subsequent higher rates of morbidity …

Toll-like receptors play an essential role in the detection of invading pathogens. TLR2 is
expressed in high concentrations on neutrophils and has been implicated as a critical …