The study of Drosophila imaginal discs has contributed to a number of discoveries in
developmental and cellular biology. In addition to the elucidation of the role of tissue …

PAX6 function was first identified through aniridia-associated null mutations. Since then, this
transcription factor, with a paired domain and a homeodomain, has become a paradigm …

Life and death fate decisions allow cells to avoid massive apoptotic death in response to
genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling …

Several eye-field transcription factors (EFTFs) are expressed in the anterior region of the
vertebrate neural plate and are essential for eye formation. The Xenopus EFTFs ET, Rx1 …

Cnidarians are widely regarded as one of the first organisms in animal evolution possessing
a nervous system. Conventional histological and electrophysiological studies have revealed …

The retina is an easily accessible part of the CNS with a well-defined cytological
architecture. It allows for detailed study of the regulation of neurogenesis, determinants of …

Light has been exploited for information by organisms through the evolution of
photoreceptors and, ultimately, eyes in animals. Only a handful of eye types exist because …

The Drosophila eye is an outstanding model with which to decipher mechanisms of neural
differentiation. Paramount to normal eye development is the organized selection and …

Neurogenesis in the zebrafish retina occurs in several waves of differentiation. The first
neurogenic wave generates ganglion cells and depends on hedgehog (hh) signaling …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by
progressive and selective loss of motor neurons. The discovery of mutations in the gene …