Fluorescence microscopy provides an efficient and unique approach to study fixed and
living cells because of its versatility, specificity, and high sensitivity. Fluorescence …

The central dogma of molecular biology—DNA makes RNA makes proteins—is a flow of
information that in eukaryotes encounters a physical barrier: the nuclear envelope, which …

Tau aggregates contribute to neurodegenerative diseases, including frontotemporal
dementia and Alzheimer's disease (AD). Although RNA promotes tau aggregation in vitro …

Circular RNAs (circRNAs) are generated from many protein-coding genes. Most accumulate
in the cytoplasm, but how circRNA localization or nuclear export is controlled remains …

In eukaryotic cells, introns are spliced from pre-mRNAs by the spliceosome. Both the
composition and the structure of the spliceosome are highly dynamic, and eight DExD/H …

Nuclear export of mRNA is an essential process for eukaryotic gene expression. The TREX
complex couples gene expression from transcription and splicing to mRNA export. Sub2, a …

Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome
and have important roles in genome evolution and function. However, the expansion of …

Human herpes viruses cause an array of illnesses ranging from cancers for Epstein–Barr
virus and Kaposi's sarcoma-associated herpes virus, to painful skin lesions, and more rarely …

Nuclear mRNA export plays an important role in gene expression. We describe the
mechanisms of mRNA export including the importance of mRNP assembly, docking with the …

Alternative splicing (AS) and fusion transcripts produce a vast expansion of transcriptomes
and proteomes diversity. However, the reliability of these events and the extend of …