Lipoxins and aspirin-triggered lipoxins in resolution of inflammation
M Romano, E Cianci, F Simiele, A Recchiuti - European journal of …, 2015 - Elsevier
The resolution of the inflammatory response is highly regulated by the timely biosynthesis of
a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers …
a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers …
Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7
The endogenous ligands for the LT, lipoxin (LX) and oxoeicosanoid receptors are bioactive
products produced by the action of the lipoxygenase family of enzymes. The LT receptors …
products produced by the action of the lipoxygenase family of enzymes. The LT receptors …
[HTML][HTML] Control of local immunity by airway epithelial cells
M Weitnauer, V Mijošek, AH Dalpke - Mucosal immunology, 2016 - Elsevier
The lung is ventilated by thousand liters of air per day. Inevitably, the respiratory system
comes into contact with airborne microbial compounds, most of them harmless …
comes into contact with airborne microbial compounds, most of them harmless …
Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis
J Simonin, E Bille, G Crambert, S Noel, E Dreano… - Scientific reports, 2019 - nature.com
Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …
Specialized proresolving mediator resolvin E1 corrects the altered cystic fibrosis nasal epithelium cilia beating dynamics
M Briottet, K Sy, C London, A Aissat… - Proceedings of the …, 2024 - National Acad Sciences
In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and
inflammation. However, cilia beating features in a CF altered environment, consisting of …
inflammation. However, cilia beating features in a CF altered environment, consisting of …
Specialized proresolving mediators in innate and adaptive immune responses in airway diseases
N Krishnamoorthy, REE Abdulnour… - Physiological …, 2018 - journals.physiology.org
Airborne pathogens and environmental stimuli evoke immune responses in the lung. It is
critical to health that these responses be controlled to prevent tissue damage and the …
critical to health that these responses be controlled to prevent tissue damage and the …
Resolution-based therapies: the potential of lipoxins to treat human diseases
RI Jaén, S Sánchez-García… - Frontiers in …, 2021 - frontiersin.org
Inflammation is an a physiological response instead an essential response of the organism
to injury and its adequate resolution is essential to restore homeostasis. However, defective …
to injury and its adequate resolution is essential to restore homeostasis. However, defective …
Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis
FC Ringholz, PJ Buchanan, DT Clarke… - European …, 2014 - Eur Respiratory Soc
Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance,
persistent bacterial infection and neutrophilic inflammation. Lipoxin A4 (LXA4) initiates the …
persistent bacterial infection and neutrophilic inflammation. Lipoxin A4 (LXA4) initiates the …
Cells and culture systems used to model the small airway epithelium
R Bhowmick, H Gappa-Fahlenkamp - Lung, 2016 - Springer
The pulmonary epithelium is divided into upper, lower, and alveolar (or small) airway
epithelia and acts as the mechanical and immunological barrier between the external …
epithelia and acts as the mechanical and immunological barrier between the external …
CFTR: a hub for kinases and crosstalk of cAMP and Ca2+
K Kunzelmann, A Mehta - The FEBS journal, 2013 - Wiley Online Library
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR). The resulting disease is pleiotropic consistent with the idea that CFTR acts as a …
(CFTR). The resulting disease is pleiotropic consistent with the idea that CFTR acts as a …