Abstract Interleukin-11 (IL-11) and IL-6 are secreted glycoproteins which fulfill important
homeostatic functions. Activation of target cells occurs via membrane-bound IL-11 and IL-6 …

Abstract Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years
ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis …

Summary Interleukin (IL)-11 has been shown to be a crucial factor for intestinal
tumorigenesis, lung carcinomas, and asthma. IL-11 is thought to exclusively mediate its …

Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11,
contributes to disease progression and poor survival outcomes in patients with colorectal …

Background Leukemia, a cancer impacting blood-forming tissues such as bone marrow and
the lymphatic system, presents in various forms, affecting children and adults differently. The …

Osteosarcoma occurs predominantly in children and young adults. High-grade tumors
require multidisciplinary treatment consisting of chemotherapy in the neoadjuvant and …

Translation of drug candidates into clinical settings requires demonstration of preclinical
efficacy and formal toxicology analysis for filling an Investigational New Drug (IND) …

Background: Interleukin-11 (IL-11) could promote invasion and metastasis of cancer cells,
however, its mechanism is unclear. Objective: This study aimed to investigate the effects of …

We previously isolated an IL-11–mimic motif (CGRRAGGSC) that binds to IL-11 receptor (IL-
11R) in vitro and accumulates in IL-11R–expressing tumors in vivo. This synthetic peptide …

Bone metabolism is the basis for maintaining the normal physiological state of bone, and
imbalance of bone metabolism can lead to a series of metabolic bone diseases. As a …