[HTML][HTML] A roadmap for the human developmental cell atlas
Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …
Oncofetal reprogramming in tumour development and progression
Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a
highly vascular microenvironment. These features are similar to those of tumour tissue, in …
highly vascular microenvironment. These features are similar to those of tumour tissue, in …
Developmental cell programs are co-opted in inflammatory skin disease
G Reynolds, P Vegh, J Fletcher, EFM Poyner… - Science, 2021 - science.org
INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …
insult through structural adaptations and interplay with the innate and adaptive immune …
Failure of human rhombic lip differentiation underlies medulloblastoma formation
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4 …
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4 …
[PDF][PDF] GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity
Pediatric cancers often mimic fetal tissues and express proteins normally silenced
postnatally that could serve as immune targets. We developed T cells expressing chimeric …
postnatally that could serve as immune targets. We developed T cells expressing chimeric …
Unified rhombic lip origins of group 3 and group 4 medulloblastoma
KS Smith, L Bihannic, BL Gudenas, P Haldipur, R Tao… - Nature, 2022 - nature.com
Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …
biologically distinct subgroups, suggesting that a personalized approach to therapy would …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
[PDF][PDF] Single-cell characterization of malignant phenotypes and developmental trajectories of adrenal neuroblastoma
R Dong, R Yang, Y Zhan, HD Lai, CJ Ye, XY Yao… - Cancer Cell, 2020 - cell.com
Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most
common extracranial solid tumor occurring in childhood. Despite extensive research, the …
common extracranial solid tumor occurring in childhood. Despite extensive research, the …
Single substitution in H3. 3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Germline histone H3. 3 amino acid substitutions, including H3. 3G34R/V, cause severe
neurodevelopmental syndromes. To understand how these mutations impact brain …
neurodevelopmental syndromes. To understand how these mutations impact brain …
[PDF][PDF] Histone H3. 3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis
Summary Histone H3. 3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …