Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Neural stem cells (NSCs) undergo massive molecular and cellular changes during neuronal
differentiation. These include mitochondria and metabolism remodelling, which were …

Aggressive and metastatic cancers show enhanced metabolic plasticity, but the precise
underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA …

Abstract Background Xuanfei Baidu Formula (XBF) is an effective traditional Chinese
medicine (TCM) remedy for treating coronavirus disease 2019 (COVID-19) in China. This …

Mitochondria are highly dynamic organelles whose fragmentation by fission is critical to their
functional integrity and cellular homeostasis. Here, we develop a method via optogenetic …

Tumours exhibit notable metabolic alterations compared with their corresponding normal
tissue counterparts. These metabolic alterations can support anabolic growth, enable …

The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from
chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of …

Mitochondrial dynamics play vital roles in the tumorigenicity and malignancy of various types
of cancers by promoting the tumor-initiating potential of cancer cells, suggesting that …

Mechanisms underlying the depletion of NAD+ and accumulation of reactive oxygen species
(ROS) in aging and age‐related disorders remain poorly defined. We show that reverse …

Currently, cancer treatment mainly consists of surgery, radiotherapy, chemotherapy,
immunotherapy, and molecular targeted therapy, of which radiotherapy is one of the major …