Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …

Although fibrosis is a final pathological feature of many chronic diseases, few interventions
are available that specifically target the pathogenesis of fibrosis. Natural products are …

The polysaccharides from Auricularia auricula (AAPs), containing a large number of O-acetyl
groups that are related to the physiological and biological properties, seem to be potential …

Highlights•Hepatic stellate cell activation/myofibroblast transition is the main driver of liver
fibrosis.•Paracrine signals from adjacent cells induce stellate cell activation.•Alteration in …

Liver disease remains a leading cause of mortality worldwide despite recent successes in
the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling …

Both thymoquinone (TQ) and thymol (T) have been proved to possess a positive impact on
human health. In this research, we aimed to investigate the effect of these compounds …