Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and
aldehydic load is a hallmark of heart failure. Recently, different research groups have …

A significant body of evidence supports the protective role of exercise training (ET) in
cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer …

Poor skeletal muscle performance was shown to strongly predict mortality and long-term
prognosis in a variety of diseases, including heart failure (HF). Despite the known benefits of …

In healthy muscle, the rapid release of calcium ions (Ca2+) with excitation–contraction (EC)
coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of …

Background Heart failure (HF) is known to lead to skeletal muscle atrophy and dysfunction.
However, intracellular mechanisms underlying HF-induced myopathy are not fully …

Aims We previously demonstrated that pharmacological activation of mitochondrial
aldehyde dehydrogenase 2 (ALDH2) protects the heart against acute ischaemia/reperfusion …

Cachexia is a prevalent pathological condition associated with chronic heart failure. Its
occurrence predicts increased morbidity and mortality independent of important clinical …

Aerobic exercise training (AET) induces several skeletal muscle changes, improving aerobic
exercise capacity and health. Conversely, to the positive effects of AET, the cachexia …

Heart failure–mediated skeletal myopathy, which is characterized by muscle atrophy and
muscle metabolism dysfunction, often manifests as dyspnea and limb muscle fatigue. We …

This review highlights some established and some more contemporary mechanisms
responsible for heart failure (HF)-induced skeletal muscle wasting and weakness. We first …