Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?
X Cao, L Ding, Z Xie, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …
[HTML][HTML] Cysteine metabolic circuitries: druggable targets in cancer
VDB Bonifácio, SA Pereira, J Serpa… - British journal of cancer, 2021 - nature.com
To enable survival in adverse conditions, cancer cells undergo global metabolic
adaptations. The amino acid cysteine actively contributes to cancer metabolic remodelling …
adaptations. The amino acid cysteine actively contributes to cancer metabolic remodelling …
International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors
C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …
Gasotransmitters in cancer: from pathophysiology to experimental therapy
C Szabo - Nature reviews Drug discovery, 2016 - nature.com
The three endogenous gaseous transmitters—nitric oxide (NO), carbon monoxide (CO) and
hydrogen sulfide (H2S)—regulate a number of key biological functions. Emerging data have …
hydrogen sulfide (H2S)—regulate a number of key biological functions. Emerging data have …
[HTML][HTML] Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production
Angiogenesis, the formation of new blood vessels by endothelial cells (ECs), is an adaptive
response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor …
response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor …
[HTML][HTML] Disturbed homocysteine metabolism is associated with cancer
T Hasan, R Arora, AK Bansal, R Bhattacharya… - … & molecular medicine, 2019 - nature.com
Hyperhomocysteinemia/Homocysteinuria is characterized by an increased level of toxic
homocysteine in the plasma. The plasma concentration of homocysteine is 5–15 μmol/L in …
homocysteine in the plasma. The plasma concentration of homocysteine is 5–15 μmol/L in …
[HTML][HTML] Hydrogen sulfide signaling in mitochondria and disease
Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …
[HTML][HTML] Cystathionine-β-synthase: molecular regulation and pharmacological inhibition
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …
pathway, is an important mammalian enzyme in health and disease. Its biochemical …
[HTML][HTML] Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
N Liu, X Lin, C Huang - British journal of cancer, 2020 - nature.com
Background Ferroptosis is an iron-dependent, lipid peroxide-mediated cell death that may
be exploited to selective elimination of damaged and malignant cells. Recent studies have …
be exploited to selective elimination of damaged and malignant cells. Recent studies have …