Manipulating and studying gene function in human pluripotent stem cell models

E Balmas, F Sozza, S Bottini, ML Ratto, G Savorè… - FEBS …, 2023 - Wiley Online Library
Human pluripotent stem cells (hPSCs) are uniquely suited to study human development and
disease and promise to revolutionize regenerative medicine. These applications rely on …

[HTML][HTML] Forward programming human pluripotent stem cells into microglia

J Csatári, H Wiendl, M Pawlowski - Trends in Cell Biology, 2024 - cell.com
Microglia play vital roles in embryonic and post-natal development, homeostasis, and
pathogen defence in the central nervous system. Human induced pluripotent stem cell …

Genome-wide CRISPR screen identifies an NF2-adherens junction mechanistic dependency for cardiac lineage

CJM Lee, MI Autio, WH Zheng, Y Song, SC Wang… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Cardiomyocyte differentiation involves a stepwise clearance of repressors
and fate-restricting regulators through the modulation of BMP (bone morphogenic …

Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian …

N Sadhu, R Dalan, PR Jain, CJM Lee, LS Pakkiri… - medRxiv, 2024 - medrxiv.org
The burden of cardiovascular disease (CVD) is rising in the Asia-Pacific region, in contrast to
falling CVD mortality rates in Europe and North America. To provide new insights into the …

乳腺生物反应器的表达优化策略

刘晓燕, 祝振亮, 史广宇, 华梓宇, 杨晨, 张涌… - 生物技术 …, 2023 - biotech.aiijournal.com
乳腺生物反应器是指将外源基因导入动物基因组并在动物乳腺中特异性表达,
利用动物乳腺合成, 分泌蛋白的功能, 在其乳汁中获得外源蛋白的技术. 乳腺生物反应器凭借其高 …

Strategies to Optimize the Expression of Mammary Gland Bioreactor

X LIU, Z ZHU, G SHI, Z HUA, C YANG… - Biotechnology …, 2023 - biotech.aiijournal.com
Mammary gland bioreactor refers to the technology of importing foreign genes into animal
genomes which express specifically in animal mammary gland, and using the function of …