The prediction of transcription factor (TF) activities from the gene expression of their targets
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …

Gene co-expression network analysis has been shown effective in identifying functional co-
expressed gene modules associated with complex human diseases. However, existing …

Successful treatment decisions in cancer depend on the accurate assessment of patient risk.
To improve our understanding of the molecular alterations that underlie deadly …

Genes, proteins, or cells influence each other and consequently create patterns, which can
be increasingly better observed by experimental biology and medicine. Thereby, descriptive …

Cutaneous melanoma is a metastatic disease characterized by high resistance to treatment,
the incidence of which has alarmingly increased worldwide over the past years. A thorough …

Conjunctival melanoma (CJM) is a rare but potentially lethal and highly-recurrent cancer of
the eye. Similar to cutaneous melanoma (CM), it originates from melanocytes. Unlike CM …

Despite the remarkable clinical response of melanoma harboring BRAF mutations to BRAF
inhibitors (BRAFi), most tumors become resistant. Here, we identified the downregulation of …

Simple Summary BCL2L10 is the sixth and less studied protein from the group of Bcl-2 anti-
apoptotic proteins. These proteins are important therapeutic targets since they convey …

The role of cyclin-dependent kinase 2 (CDK2) in cancer is controversial. A major hurdle is
the availability of tools to easily assess its activity across many samples. Here, we introduce …

Reactive oxygen species (ROS) are implicated in tumor transformation. The antioxidant
system (AOS) protects cells from ROS damage. However, it is also hijacked by cancers cells …