Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues

RHB Benedict, MP Amato, J DeLuca… - The Lancet …, 2020 - thelancet.com
Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

Language impairments in people with autoimmune neurological diseases: A scoping review

J Rook, S Llufriu, D de Kok, A Rofes - Journal of Communication Disorders, 2023 - Elsevier
Abstract Introduction Autoimmune neurological diseases (ANDs) are a specific type of
autoimmune disease that affect cells within the central and peripheral nervous system …

The Symbol Digit Modalities Test (SDMT) is sensitive but non-specific in MS: Lexical access speed, memory, and information processing speed independently …

J Sandry, DV Simonet, R Brandstadter, S Krieger… - Multiple sclerosis and …, 2021 - Elsevier
Abstract Background The Symbol Digit Modalities Test (SDMT) is the most sensitive metric of
neurocognitive function in multiple sclerosis (MS), and is consistently interpreted as a …

Staging and stratifying cognitive dysfunction in multiple sclerosis

C Wojcik, TA Fuchs, H Tran, MG Dwyer… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: The sequence in which cognitive domains become impaired in multiple
sclerosis (MS) is yet to be formally demonstrated. It is unclear whether processing speed …

[HTML][HTML] Cognitive processes underlying verbal fluency in multiple sclerosis

A Delgado-Álvarez, JA Matias-Guiu… - Frontiers in …, 2021 - frontiersin.org
Background: Verbal fluency (VF) has been associated with several cognitive functions, but
the cognitive processes underlying verbal fluency deficits in Multiple Sclerosis (MS) are …

[HTML][HTML] Social support is linked to mental health, quality of life, and motor function in multiple sclerosis

A Kever, K Buyukturkoglu, CS Riley, PL De Jager… - Journal of …, 2021 - Springer
Objective To investigate associations of social support to psychological well-being,
cognition, and motor functioning in patients with multiple sclerosis (MS). Secondarily, we …

EDSS 0 is not normal: Multiple sclerosis disease burden below the clinical threshold

SC Krieger, A Antoine… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Little to no above-threshold deficits may be evident in early multiple sclerosis (MS). The
Expanded Disability Status Scale (EDSS) is a standard measure of neurologic function, with …

Classifying multiple sclerosis patients on the basis of SDMT performance using machine learning

K Buyukturkoglu, D Zeng, S Bharadwaj… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Objective: To build a model to predict cognitive status reflecting structural, functional, and
white matter integrity changes in early multiple sclerosis (MS). Methods: Based on Symbol …

The role of language ability in verbal fluency of individuals with multiple sclerosis

AL Lebkuecher, ND Chiaravalloti, LB Strober - Multiple sclerosis and …, 2021 - Elsevier
Background While cognitive deficits in memory and processing speed have been well-
documented in individuals with multiple sclerosis (MS), language is largely considered to be …

Machine learning to investigate superficial white matter integrity in early multiple sclerosis

K Buyukturkoglu, C Vergara… - Journal of …, 2022 - Wiley Online Library
Abstract Background and Purpose This study aims todetermine the sensitivity of superficial
white matter (SWM) integrity as a metric to distinguish early multiple sclerosis (MS) patients …