Vaccines are arguably the most powerful medical intervention in the fight against infectious
diseases. The enormity of the global human immunodeficiency virus type 1 (HIV)/acquired …

Recent experimental observations suggest approaches to immunization that might finally
result in at least a partially effective vaccine against infection with HIV-1. In particular …

Replication-defective adenovirus (ADV) vectors represent a promising potential platform for
the development of a vaccine for AIDS. Although this vector is typically administered …

Acute simian immunodeficiency virus (SIV)/human immunodeficiency virus infection is
accompanied by a massive destruction of CD4 memory T cells across all the tissue …

The initial site of exposure to human immunodeficiency virus (HIV)–1 during heterosexual
transmission occurs in the genital tract. Although the majority of immunological studies have …

Candidate HIV-1 vaccine regimens utilizing intramuscularly (im) administered recombinant
adenovirus (rAd)-based vectors can induce potent mucosal cellular immunity. However, the …

The use of a number of non-rhesus macaque species, but especially cynomolgus macaques
as a model for HIV-1 vaccine development has increased in recent years. Cynomolgus …

Recent progress in HIV-1 and SIV pathogenesis has revealed that mucosal tissues, primarily
the gastrointestinal tract, are major sites for early viral replication and CD4+ T-cell …

The development of HIV‐1 vaccines and microbicides remains hindered by our limited
understanding of correlates of immune protection to infection. Evidence indicating that …

Naïve Indian rhesus macaques were immunized with a mixture of optimized plasmid DNAs
expressing several SIV antigens using in vivo electroporation via the intramuscular route …