Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Acute respiratory distress syndrome (ARDS) is a fatal complication of influenza infection. In
this Review we provide an integrated model for its pathogenesis. ARDS involves damage to …

Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed.
Administering bone marrow stromal cells (BMSCs—also known as mesenchymal stem cells) …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

One of the major therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial necrosis and optimizing cardiac repair following myocardial …

This review addresses recent advances in specific mechanisms of hepatotoxicity. Because
of its unique metabolism and relationship to the gastrointestinal tract, the liver is an important …

CONCLUSION The notion that inflammation is the net resultant of pro and contra
inflammatory pathways (Fauve, 1980) is well illustrated by the dual role of neutrophils which …

Liver cell death induced by stresses such as ischemia‐reperfusion, cholestasis and drug
toxicity can trigger a sterile inflammatory response with activation of innate immune cells …

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …