Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

One way to preserve a rare book is to lock it away from all potential sources of damage. Of
course, an inaccessible book is also of little use, and the paper and ink will continue to …

The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has
recently gained interest, and different DDR inhibitors have been developed. Among them …

Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour
types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro …

Human cleavage-stage embryos frequently acquire chromosomal aneuploidies during
mitosis due to unknown mechanisms. Here, we show that S phase at the 1-cell stage shows …

Oncogene activation creates DNA replication stress (RS) in cancer cells, which can
generate under-replicated DNA regions (UDRs) that persist until cells enter mitosis. UDRs …

Proliferating cells rely on the so-called DNA replication checkpoint to ensure orderly
completion of genome duplication, and its malfunction may lead to catastrophic genome …

Formation of co-transcriptional R-loops underlies replication fork stalling upon head-on
transcription-replication encounters. Here, we demonstrate that RAD51-dependent …

Flaws in the DNA replication process have emerged as a leading driver of genome
instability in human diseases. Alteration to replication fork progression is a defining feature …