The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Abstract Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that has
important roles in regulating energy balance and glucose and lipid homeostasis through a …
important roles in regulating energy balance and glucose and lipid homeostasis through a …
[HTML][HTML] The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Caltech-UW TMC Cai Long lcai@ caltech. edu 21 b … - Nature, 2019 - nature.com
Transformative technologies are enabling the construction of three-dimensional maps of
tissues with unprecedented spatial and molecular resolution. Over the next seven years, the …
tissues with unprecedented spatial and molecular resolution. Over the next seven years, the …
A reference map of the human binary protein interactome
K Luck, DK Kim, L Lambourne, K Spirohn, BE Begg… - Nature, 2020 - nature.com
Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …
understanding of the interactome networks that mediate genotype–phenotype relationships …
AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors
Abstract The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to
provide the most comprehensive and accurate information for animal transcription factors …
provide the most comprehensive and accurate information for animal transcription factors …
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
Tremendous amount of RNA sequencing data have been produced by large consortium
projects such as TCGA and GTEx, creating new opportunities for data mining and deeper …
projects such as TCGA and GTEx, creating new opportunities for data mining and deeper …
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants
The information about the genetic basis of human diseases lies at the heart of precision
medicine and drug discovery. However, to realize its full potential to support these goals …
medicine and drug discovery. However, to realize its full potential to support these goals …
[HTML][HTML] Massive mining of publicly available RNA-seq data from human and mouse
RNA sequencing (RNA-seq) is the leading technology for genome-wide transcript
quantification. However, publicly available RNA-seq data is currently provided mostly in raw …
quantification. However, publicly available RNA-seq data is currently provided mostly in raw …
[HTML][HTML] Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
Summary The Cancer Genome Atlas revealed the genomic landscapes of human cancers.
In parallel, immunotherapy is transforming the treatment of advanced cancers. Unfortunately …
In parallel, immunotherapy is transforming the treatment of advanced cancers. Unfortunately …
[HTML][HTML] WormBase ParaSite− a comprehensive resource for helminth genomics
The number of publicly available parasitic worm genome sequences has increased
dramatically in the past three years, and research interest in helminth functional genomics is …
dramatically in the past three years, and research interest in helminth functional genomics is …
[HTML][HTML] Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy
Immune-related adverse events (irAEs), caused by anti-PD-1/PD-L1 antibodies, can lead to
fulminant and even fatal consequences and thus require early detection and aggressive …
fulminant and even fatal consequences and thus require early detection and aggressive …