Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
RNA/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-loop-associated DNA damage
R-loops comprise an RNA/DNA hybrid and displaced single-stranded DNA. They play
important biological roles and are implicated in pathology. Even so, proteins recognizing …
important biological roles and are implicated in pathology. Even so, proteins recognizing …
Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks
A Cristini, G Ricci, S Britton, S Salimbeni, SN Huang… - Cell reports, 2019 - cell.com
Although accumulation of DNA damage and genomic instability in resting cells can cause
neurodegenerative disorders, our understanding of how transcription produces DNA double …
neurodegenerative disorders, our understanding of how transcription produces DNA double …
DNA Topoisomerase I differentially modulates R-loops across the human genome
Background Co-transcriptional R-loops are abundant non-B DNA structures in mammalian
genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing …
genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing …
Transcriptional firing helps to drive NETosis
MA Khan, N Palaniyar - Scientific reports, 2017 - nature.com
Neutrophils are short-lived innate immune cells. These cells respond quickly to stimuli, and
die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains …
die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains …
TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation
MM Suzuki, K Iijima, K Ogami, K Shinjo… - Nature …, 2023 - nature.com
Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop
formation are known to impede S phase progression. Nonetheless, cancer cells …
formation are known to impede S phase progression. Nonetheless, cancer cells …
The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats
ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated
sequences including telomeres (TTAGGG) n. ATRX mutations are found in nearly all …
sequences including telomeres (TTAGGG) n. ATRX mutations are found in nearly all …
Type i DNA topoisomerases
G Capranico, J Marinello… - Journal of medicinal …, 2017 - ACS Publications
DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …
of life. Although they share general reaction chemistry and the capacity to govern DNA …
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
S Silva, LP Camino, A Aguilera - Proceedings of the …, 2018 - National Acad Sciences
R loops are nucleic acid structures comprising an DNA–RNA hybrid and a displaced single-
stranded DNA. These structures may occur transiently during transcription, playing essential …
stranded DNA. These structures may occur transiently during transcription, playing essential …