The endothelial cells that compose the vascular system in the body display a wide range of
mechanotransductive behaviors and responses to biomechanical stimuli, which act in …

Highlights•Pseudoenzymes are structural, but catalytically defective, homologs of
enzymes.•Examples of pseudoenzymes have been identified in all kingdoms of …

Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

The Rho family GTPases are small G proteins that act as molecular switches shuttling
between active and inactive forms. Rho GTPases are regulated by two classes of regulatory …

The rapid development of synchrotrons has massively increased the speed at which
experiments can be performed, while new techniques have increased the amount of raw …

Semaphorins were originally identified as axonal guidance molecules, but they also control
processes such as vascular development and tumorigenesis. The downstream signaling …

Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily
represent a large family of proteins involved in several key cellular mechanisms. Within the …

Expression of transmembrane protein 16 A (TMEM16A), a calcium activated chloride
channel, is elevated in some human cancers and impacts tumor cell proliferation …

The pseudokinase group encompasses some 10% of protein kinases, but pseudokinases
diverge from canonical kinases in key motifs. The two members of the small new kinase …

Introduction Appropriate implantation of trophoblast cells is necessary for successful
pregnancy outcome. This process requires proper migration and invasion of trophoblast …