Carbon ion radiobiology

W Tinganelli, M Durante - Cancers, 2020 - mdpi.com
Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …

Charged particle therapy—optimization, challenges and future directions

JS Loeffler, M Durante - Nature reviews Clinical oncology, 2013 - nature.com
The use of charged particle therapy to control tumours non-invasively offers advantages
over conventional radiotherapy. Protons and heavy ions deposit energy far more selectively …

Report of the AAPM TG‐256 on the relative biological effectiveness of proton beams in radiation therapy

H Paganetti, E Blakely, A Carabe‐Fernandez… - Medical …, 2019 - Wiley Online Library
The biological effectiveness of proton beams relative to photon beams in radiation therapy
has been taken to be 1.1 throughout the history of proton therapy. While potentially …

Hypoxic radioresistance: can ROS be the key to overcome it?

H Wang, H Jiang, M Van De Gucht, M De Ridder - Cancers, 2019 - mdpi.com
Radiotherapy is a mainstay treatment for many types of cancer and kills cancer cells via
generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological …

RBE and related modeling in carbon-ion therapy

CP Karger, P Peschke - Physics in Medicine & Biology, 2017 - iopscience.iop.org
Carbon ion therapy is a promising evolving modality in radiotherapy to treat tumors that are
radioresistant against photon treatments. As carbon ions are more effective in normal and …

CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges

P Grosse‐Gehling, CA Fargeas, C Dittfeld… - The Journal of …, 2013 - Wiley Online Library
The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …

Carbon ion radiotherapy: a review of clinical experiences and preclinical research, with an emphasis on DNA damage/repair

O Mohamad, BJ Sishc, J Saha, A Pompos, A Rahimi… - Cancers, 2017 - mdpi.com
Compared to conventional photon-based external beam radiation (PhXRT), carbon ion
radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and …

Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: potential role of hypoxia

DT Marie-Egyptienne, I Lohse, RP Hill - Cancer letters, 2013 - Elsevier
Numerous studies have demonstrated the presence of cancer stem cells (CSCs) within solid
tumors. Although the precursor of these cells is not clearly established, recent studies …

Hadron therapy, magnetic nanoparticles and hyperthermia: A promising combined tool for pancreatic cancer treatment

F Brero, M Albino, A Antoccia, P Arosio, M Avolio… - Nanomaterials, 2020 - mdpi.com
A combination of carbon ions/photons irradiation and hyperthermia as a novel therapeutic
approach for the in-vitro treatment of pancreatic cancer BxPC3 cells is presented. The …

Particle radiotherapy with carbon ion beams

T Ohno - EPMA Journal, 2013 - Springer
Carbon ion radiotherapy offers superior dose conformity in the treatment of deep-seated
malignant tumours compared with conventional X-ray therapy. In addition, carbon ion beams …