The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

In the pharmaceutical industry, poorly water-soluble drugs require enabling technologies to
increase apparent solubility in the biological environment. Amorphous solid dispersion …

Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for
their successful approval for market. ASD stability does not only depend on the interplay …

The perturbed chain-statistical associating fluid theory equation of state (PC-SAFT EoS) is
one of the state-of-the-art thermodynamic models used in the phase equilibrium calculation …

During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …

Amorphous solid dispersions (ASDs) are commonly manufactured using spray-drying
processes. The product quality can be decisively influenced by the choice of process …

In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-
soluble active pharmaceutical ingredients (APIs) in so-called “amorphous solid …

There has been much recent interest in machine learning (ML) and molecular quantitative
structure property relationships (QSPR). The present research evaluated modern ML-based …

In spite of the fact that spray drying is widely applied for the formulation of amorphous solid
dispersions (ASDs), the influence of the solvent on the physical properties of the ASDs is still …

Understanding and prevention of unwanted changes of a pharmaceutical formulation during
the production process is part of the critical requirements for the successful approval of a …