Hepatocellular carcinoma (HCC) is the most common liver tumor and among the deadliest
cancers worldwide. Advanced HCC overall survival is meager and has not improved over …

Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …

Importance The treatment landscape of metastatic renal cell carcinoma has evolved rapidly
over the last decade. Recent combination approaches heralded by targeting immune …

Long-term antitumor efficacy of chimeric antigen receptor (CAR) T cells depends on their
functional persistence in vivo. T cells with stem-like properties show better persistence, but …

Tumor immunotherapy is considered to be a novel and promising therapy for tumors and it
has recently become a hot research topic. The clinical success of tumor immunotherapy has …

T cells play a crucial role in the regulation of immune response and are integral to the
efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising …

The mechanisms underlying the efficacy of anti-programmed cell death protein 1 (PD-1) and
anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) therapy are incompletely …

Whereas terminally exhausted T (Tex_term) cells retain anti-tumor cytotoxic functions, the
frequencies of stem-like progenitor-exhausted T (Tex_prog) cells better reflect …

Cancer immunotherapy relies on improving T cell effector functions against malignancies,
but despite the identification of several key transcription factors (TFs), the biological …

Hypothalamic aging is considered to be critical for systemic aging, and the accumulation of
“exhausted glial cells” in the hypothalamus may contribute to brain dysfunction. In this study …