Memory consolidation refers to the transformation over time of experience-dependent
internal representations and their neurobiological underpinnings. The process is assumed …

Targeted memory reactivation (TMR) is a methodology employed to manipulate memory
processing during sleep. TMR studies have great potential to advance understanding of …

Since Freud, clinicians have understood that disturbing memories contribute to
psychopathology and that new emotional experiences contribute to therapeutic change. Yet …

The generalization of fear memories is an adaptive neurobiological process that promotes
survival in complex and dynamic environments. When confronted with a potential threat, an …

Sleep benefits memory consolidation. Previous theoretical accounts have proposed a
differential role of slow-wave sleep (SWS), rapid-eye-movement (REM) sleep, and stage N2 …

Learning and memory for extinction of conditioned fear is a basic mammalian mechanism for
regulating negative emotion. Sleep promotes both the consolidation of memory and the …

Poor sleep is associated with the risk of developing chronic pain, but how sleep contributes
to pain chronicity remains unclear. Here we show that following peripheral nerve injury …

Sleep is essential for effective cognitive functioning. Loosing even a few hours of sleep can
have detrimental effects on a wide variety of cognitive processes such as attention …

Sleep is a highly conserved phenomenon in endotherms, and therefore it must serve at least
one basic function across this wide range of species. What that function is remains one of …

Highlights•Hippocampal SWRs contain neural activity reactivations in both waking and
sleeping.•SWRs in waking and sleeping entail distinct features, particularly replay …