Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

This article focuses on recent findings that the type V TGF‐β receptor (TβR‐V), which co‐
expresses with other TGF‐β receptors (TβR‐I, TβR‐II, and TβR‐III) in all normal cell types …

Activation of hepatic stellate cells (HSCs) is the key step in liver fibrogenesis. Increased
transforming growth factor β (TGF-β) expression and extracellular matrix production in …

Transforming growth factor (TGF)-β is a natural and potent growth inhibitor of a variety of cell
types, including epithelial, endothelial, and hematopoietic cells. The ability of TGF-β to …

Smad proteins are essential components of the signalling cascade initiated by members of
the Transforming Growth Factor-β family. TGFβ binding to heteromeric complexes of …

The TGF-β superfamily of growth and differentiation factors, including TGF-β, Activins and
bone morphogenetic proteins (BMPs) play critical roles in regulating the development of …

Tissue fibrosis is one of the characteristics of chronic pancreatitis and pancreatic
adenocarcinoma. Activated pancreatic stellate cells (PSC) play a central role in this process …

The type V TGF‐β receptor (TβR‐V)/IGFBP‐3 receptor mediates the IGF‐independent
growth inhibition induced by IGFBP‐3. It also mediates the growth inhibitory response to …

Bone marrow stromal cells (BMSCs) are strong candidates for cell therapy against human
autoimmune diseases. Intravenous administration of syngenic BMSCs to EAMG-model rats …

Several families of growth factors have been identified as regulators of cell fate in the
developing lens. Members of the fibroblast growth factor family are potent inducers of lens …