New tricks for an old pathway: emerging Notch-based biotechnologies and therapeutics
E Medina, DH Perez, D Antfolk, VC Luca - Trends in Pharmacological …, 2023 - cell.com
The Notch pathway regulates a diverse array of cell fate decisions, making it an enticing
target in cancer therapy and regenerative medicine. During the early stages of Notch drug …
target in cancer therapy and regenerative medicine. During the early stages of Notch drug …
Enabling neighbour labelling: using synthetic biology to explore how cells influence their neighbours
M Malaguti, T Lebek, G Blin, S Lowell - Development, 2024 - journals.biologists.com
Cell-cell interactions are central to development, but exploring how a change in any given
cell relates to changes in the neighbour of that cell can be technically challenging. Here, we …
cell relates to changes in the neighbour of that cell can be technically challenging. Here, we …
Post-Transcriptional Modular Synthetic Receptors
Inspired by the power of transcriptional synthetic receptors and hoping to complement them
to expand the toolbox for cell engineering, we establish LIDAR (Ligand-Induced …
to expand the toolbox for cell engineering, we establish LIDAR (Ligand-Induced …
Small molecule and cell contact-inducible systems for controlling expression and differentiation in stem cells
Synthetic developmental biology uses engineering approaches to understand
multicellularity with goals ranging from recapitulating development to building synthetic …
multicellularity with goals ranging from recapitulating development to building synthetic …