Cancer therapy is one of the most important challenges of modern medical and chemical
sciences. Among the many methods of combating cancer, chemotherapy plays a special …

Isodon rubescens has been used as a traditional green tea for more than 1000 years and
many medicinal functions of I. rubescens are also very useful, such as its well-known …

The first series of nitric oxide donating derivatives of evodiamine were designed and
prepared. NO releasing ability of all target derivatives was evaluated in BGC-823, Bel-7402 …

Isoalantolactone possessed various biological activities. However, whether it could treat
breast cancer and its underlying mechanism remained largely unknown. This study was …

The discovery of cytotoxic drugs is focused on designing a compound structure that directly
affects cancer cells without an impact on normal cells. The mechanism of anticancer activity …

Background: Triple-negative breast cancer accounts for approximately 15–20% of all breast
carcinomas and is associated with earlier age of onset, aggressive clinical course, and …

In this innovative research, we aim to reveal pyrazole-based Schiff bases as new multi-target
agents. In this context, we re-synthesized three sets of pyrazole-based Schiff bases, 5a–f, 6a …

Background A large number of studies have shown a close relationship between ADORA2A
and the pathological mechanism of schizophrenia. However, to our knowledge, there has …

Many studies have shown that naturally occurring compounds may support prevention and
treatment of various diseases, including cancer. Pharmacological investigations revealed a …

Abstract A series of six 2, 5-disubstituted 1, 3, 4-thiadiazole derivatives was synthesized and
examined for cytotoxic activity in MCF-7 and MDA-MB-231 breast cancer cells. MTT assay …