The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

Cells sense mechanical stress and changes in their matrix environment through the
integrins, a family of heterodimeric surface receptors that bind to extracellular matrix ligands …

The cardiac vascular and perivascular niche are of major importance in homeostasis and
during disease, but we lack a complete understanding of its cellular heterogeneity and …

BACKGROUND: Pericytes have been implicated in tissue repair, remodeling, and fibrosis.
Although the mammalian heart contains abundant pericytes, their fate and involvement in …

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

CD34+ cells improve the perfusion and function of ischemic limbs in humans and mice.
However, there is no direct evidence of the differentiation potential and functional role of …

Reliable tools for macrophage identification in mouse tissues are critical for studies
investigating inflammatory and reparative responses. Transgenic reporter mice and anti …

The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …

Pericytes (PCs), as a central component of the neurovascular unit, contribute to the
regenerative potential of the central nervous system (CNS) and peripheral nervous system …

Millions of cardiomyocytes die immediately after myocardial infarction, regardless of whether
the culprit coronary artery undergoes prompt revascularization. Residual ischaemia in the …