A mini review of nervonic acid: Source, production, and biological functions
Q Li, J Chen, X Yu, JM Gao - Food chemistry, 2019 - Elsevier
Nervonic acid (NA) has attracted considerable attention because of its close relationship
with brain development. Sources of NA include oil crop seeds, oil-producing microalgae …
with brain development. Sources of NA include oil crop seeds, oil-producing microalgae …
Nervonic acid and its sphingolipids: Biological functions and potential food applications
NV Phung, F Rong, WY Xia, Y Fan, XY Li… - Critical reviews in …, 2023 - Taylor & Francis
Nervonic acid, a 24-carbon fatty acid with only one double bond at the 9th carbon (C24: 1n-
9), is abundant in the human brain, liver, and kidney. It not only functions in free form but …
9), is abundant in the human brain, liver, and kidney. It not only functions in free form but …
Combining orthogonal plant and non-plant fatty acid biosynthesis pathways for efficient production of microbial oil enriched in nervonic acid in Yarrowia lipolytica
K Wang, L Lin, P Wei, R Ledesma-Amaro, XJ Ji - Bioresource Technology, 2023 - Elsevier
Nervonic acid has proven efficacy in brain development and the prevention of
neurodegenerative diseases. Here, an alternative and sustainable strategy for nervonic acid …
neurodegenerative diseases. Here, an alternative and sustainable strategy for nervonic acid …
The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
Background The risk for dementia increases exponentially from the seventh decade of life.
Identifying and understanding the biochemical changes that sensitize the ageing brain to …
Identifying and understanding the biochemical changes that sensitize the ageing brain to …
A review of nervonic acid production in plants: prospects for the genetic engineering of high nervonic acid cultivars plants
F Liu, P Wang, X Xiong, X Zeng, X Zhang… - Frontiers in Plant …, 2021 - frontiersin.org
Nervonic acid (NA) is a very-long-chain monounsaturated fatty acid that plays crucial roles in
brain development and has attracted widespread research interest. The markets …
brain development and has attracted widespread research interest. The markets …
Endoplasmic reticulum stress and mitochondrial dysfunction during aging: role of sphingolipids
Q Chen, A Kovilakath, J Allegood, J Thompson… - … et Biophysica Acta (BBA …, 2023 - Elsevier
The endoplasmic reticulum (ER) plays a key role in the regulation of protein folding, lipid
synthesis, calcium homeostasis, and serves as a primary site of sphingolipid biosynthesis …
synthesis, calcium homeostasis, and serves as a primary site of sphingolipid biosynthesis …
Brain areas lipidomics in female transgenic mouse model of Alzheimer's disease
L Ferré-González, Á Balaguer, M Roca, A Ftara… - Scientific reports, 2024 - nature.com
Lipids are the major component of the brain with important structural and functional
properties. Lipid disruption could play a relevant role in Alzheimer's disease (AD). Some …
properties. Lipid disruption could play a relevant role in Alzheimer's disease (AD). Some …
Fatty acids and beyond: Age and Alzheimer's disease related changes in lipids reveal the neuro-nutraceutical potential of lipids in cognition
Lipids are essential in maintaining brain function, and lipid profiles have been reported to be
altered in aged and Alzheimer's disease (AD) brains as compared to healthy mature brains …
altered in aged and Alzheimer's disease (AD) brains as compared to healthy mature brains …
The cross-talk between sphingolipids and insulin-like growth factor signaling: significance for aging and neurodegeneration
H Jęśko, A Stępień, WJ Lukiw, RP Strosznajder - Molecular Neurobiology, 2019 - Springer
Abstract Bioactive sphingolipids: sphingosine, sphingosine-1-phosphate (S1P), ceramide,
and ceramide-1-phosphate (C1P) are increasingly implicated in cell survival, proliferation …
and ceramide-1-phosphate (C1P) are increasingly implicated in cell survival, proliferation …
Inhibition of nSMase2 reduces the transfer of oligomeric α-synuclein irrespective of hypoxia
V Sackmann, MS Sinha, C Sackmann… - Frontiers in molecular …, 2019 - frontiersin.org
Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an
influential role in the cell-to-cell spread of neurodegenerative diseases, including the …
influential role in the cell-to-cell spread of neurodegenerative diseases, including the …