Adoptive T cell therapy has achieved dramatic success in a clinic, and the Food and Drug
Administration approved two chimeric antigen receptor-engineered T cell (CAR-T) therapies …

The T-cell receptor (TCR) functions in both antigen recognition and signal transduction,
which are crucial initial steps of antigen-specific immune responses. TCR integrity is vital for …

Ag-specific T cell tolerance plays a critical role in tumor escape. Recent studies implicated
myeloid-derived suppressor cells (MDSCs) in the induction of CD8+ T cell tolerance in tumor …

A long-standing paradox in the study of T cell antigen recognition is that of the high
specificity–low affinity T cell receptor (TCR)–major histocompatibility complex peptide …

The immune system distinguishes between self and foreign antigens. The kinetic
proofreading (KPR) model proposes that T cells discriminate self from foreign ligands by the …

Summary T cell receptor (TCR-CD3) triggering involves both receptor clustering and
conformational changes at the cytoplasmic tails of the CD3 subunits. The mechanism by …

We present a robust and general method for the identification and relative quantification of
phosphorylation sites in complex protein mixtures. It is based on a new chemical …

1270 upon ligand recognition by the TCR (Kane et al., 2000). A significant proportion of Lck
in the cell constitutively associates with the coreceptor CD4. Because CD4 also interacts …

Improvements in surgical techniques and availability of immunosuppressive options have
led to current successes in the arena of solid organ transplantation. Historically …

T cells have an amazing ability to discern and differentially respond to MHC-embedded
peptides that can differ by only a single amino acid. This potential involves a combination of …