Principles and applications of nucleic acid strand displacement reactions

FC Simmel, B Yurke, HR Singh - Chemical reviews, 2019 - ACS Publications
Dynamic DNA nanotechnology, a subfield of DNA nanotechnology, is concerned with the
study and application of nucleic acid strand-displacement reactions. Strand-displacement …

Synthetic DNA applications in information technology

LC Meiser, BH Nguyen, YJ Chen, J Nivala… - Nature …, 2022 - nature.com
Synthetic DNA is a growing alternative to electronic-based technologies in fields such as
data storage, product tagging, or signal processing. Its value lies in its characteristic …

A PAM-free CRISPR/Cas12a ultra-specific activation mode based on toehold-mediated strand displacement and branch migration

Y Wu, W Luo, Z Weng, Y Guo, H Yu… - Nucleic Acids …, 2022 - academic.oup.com
CRISPR (clustered regularly interspaced short palindromic repeats) technology has
achieved great breakthroughs in terms of convenience and sensitivity; it is becoming the …

Catalytic self-assembly of quantum-dot-based microRNA nanosensor directed by toehold-mediated strand displacement cascade

F Ma, Q Zhang, C Zhang - Nano Letters, 2019 - ACS Publications
Semiconductor quantum dots (QDs) are highly attractive nanomaterials with wide
biomedical applications owing to their unique photophysical properties. However, the …

Highly specific SNP detection using 2D graphene electronics and DNA strand displacement

MT Hwang, PB Landon, J Lee, D Choi… - Proceedings of the …, 2016 - National Acad Sciences
Single-nucleotide polymorphisms (SNPs) in a gene sequence are markers for a variety of
human diseases. Detection of SNPs with high specificity and sensitivity is essential for …

Unmodificated stepless regulation of CRISPR/Cas12a multi-performance

R Zhao, W Luo, Y Wu, L Zhang, X Liu, J Li… - Nucleic Acids …, 2023 - academic.oup.com
As CRISPR technology is promoted to more fine-divided molecular biology applications, its
inherent performance finds it increasingly difficult to cope with diverse needs in these …

Application of hairpin DNA-based biosensors with various signal amplification strategies in clinical diagnosis

R Abolhasan, A Mehdizadeh, MR Rashidi… - Biosensors and …, 2019 - Elsevier
Biosensors have been commonly used in biomedical diagnostic tools in recent years,
because of a wide range of application, such as point-of-care monitoring of treatment and …

Endogenous microRNA accurate diagnostics to guide photothermal therapy

F Yang, Q Yang, L Yang, J Li, Y Zhang, H Lu… - Analytical …, 2022 - ACS Publications
Developing an intelligent theranostic nanoplatform with satisfied diagnostic accuracy and
therapeutic efficiency holds great promise for personalized nanomedicine. Herein, we …

DNA strand displacement reaction: a powerful tool for discriminating single nucleotide variants

W Tang, W Zhong, Y Tan, GA Wang, F Li… - … : From Structure to …, 2020 - Springer
Single-nucleotide variants (SNVs) that are strongly associated with many genetic diseases
and tumors are important both biologically and clinically. Detection of SNVs holds great …

Twinkle-catalyzed toehold-mediated DNA strand displacement reaction

A Singh, G Patel, SS Patel - Journal of the American Chemical …, 2023 - ACS Publications
Strand exchange between homologous nucleic acid sequences is the basis for cellular DNA
repair, recombination, and genome editing technologies. Specialized enzymes catalyze …