Crossing the blood-brain barrier: advances in nanoparticle technology for drug delivery in neuro-oncology
The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …
Design and synthesis of SERS materials for in vivo molecular imaging and biosensing
Q Li, H Huo, Y Wu, L Chen, L Su, X Zhang… - Advanced …, 2023 - Wiley Online Library
Surface‐enhanced Raman scattering (SERS) is a feasible and ultra‐sensitive method for
biomedical imaging and disease diagnosis. SERS is widely applied to in vivo imaging due …
biomedical imaging and disease diagnosis. SERS is widely applied to in vivo imaging due …
Blood–brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound
N Lipsman, Y Meng, AJ Bethune, Y Huang… - Nature …, 2018 - nature.com
Magnetic resonance-guided focused ultrasound in combination with intravenously injected
microbubbles has been shown to transiently open the blood–brain barrier, and reduce beta …
microbubbles has been shown to transiently open the blood–brain barrier, and reduce beta …
Applications of Raman spectroscopy in cancer diagnosis
Novel approaches toward understanding the evolution of disease can lead to the discovery
of biomarkers that will enable better management of disease progression and improve …
of biomarkers that will enable better management of disease progression and improve …
Progress in brain targeting drug delivery system by nasal route
AR Khan, M Liu, MW Khan, G Zhai - Journal of Controlled Release, 2017 - Elsevier
The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
Strategies for transporting nanoparticles across the blood–brain barrier
The existence of blood–brain barrier (BBB) hampers the effective treatment of central
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
Focused ultrasound-mediated drug delivery through the blood–brain barrier
A Burgess, K Shah, O Hough… - Expert review of …, 2015 - Taylor & Francis
Despite recent advances in blood–brain barrier (BBB) research, it remains a significant
hurdle for the pharmaceutical treatment of brain diseases. Focused ultrasound (FUS) is one …
hurdle for the pharmaceutical treatment of brain diseases. Focused ultrasound (FUS) is one …
Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood− brain barrier using MRI-guided focused ultrasound
The blood–brain barrier (BBB) presents a significant obstacle for the treatment of many
central nervous system (CNS) disorders, including invasive brain tumors, Alzheimer's …
central nervous system (CNS) disorders, including invasive brain tumors, Alzheimer's …
First noninvasive thermal ablation of a brain tumor with MR-guided focusedultrasound
D Coluccia, J Fandino, L Schwyzer… - Journal of therapeutic …, 2014 - Springer
Magnetic resonance-guided focused ultrasound surgery (MRgFUS) allows for
precisethermal ablation of target tissues. While this emerging modality is increasinglyused …
precisethermal ablation of target tissues. While this emerging modality is increasinglyused …