Improving translation of animal models of addiction and relapse by reverse translation

M Venniro, ML Banks, M Heilig, DH Epstein… - Nature Reviews …, 2020 - nature.com
Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Adenovirus: The First Effective In Vivo Gene Delivery Vector

RG Crystal - Human gene therapy, 2014 - liebertpub.com
The adenovirus, an 80–100 nm, nonenveloped, icosa-hedral capsid, double-stranded DNA
virus, is a wellknown cause of respiratory tract infections (Ginsberg, 1984). Adenovirus …

The neurobiology of addiction

GR Uhl, GF Koob, J Cable - Annals of the New York Academy …, 2019 - Wiley Online Library
Substance and alcohol use disorders impose large health and economic burdens on
individuals, families, communities, and society. Neither prevention nor treatment efforts are …

Development of vaccines to treat opioid use disorders and reduce incidence of overdose

M Pravetoni, SD Comer - Neuropharmacology, 2019 - Elsevier
Vaccines offer a promising therapeutic strategy to treat substance use disorders (SUD).
Vaccines have shown extensive preclinical proof of selectivity, safety, and efficacy against …

[图书][B] The myth of the moral brain: The limits of moral enhancement

H Wiseman - 2016 - books.google.com
An argument that moral functioning is immeasurably complex, mediated by biology but not
determined by it. Throughout history, humanity has been seen as being in need of …

Environmental, genetic and epigenetic contributions to cocaine addiction

RC Pierce, B Fant, SE Swinford-Jackson… - …, 2018 - nature.com
Decades of research on cocaine has produced volumes of data that have answered many
important questions about the nature of this highly addictive drug. Sadly, none of this …

Conjugate vaccine immunotherapy for substance use disorder

PT Bremer, KD Janda - Pharmacological reviews, 2017 - ASPET
Substance use disorder, especially in relation to opioids such as heroin and fentanyl, is a
significant public health issue and has intensified in recent years. As a result, substantial …

Development of a clinically viable heroin vaccine

PT Bremer, JE Schlosburg, ML Banks… - Journal of the …, 2017 - ACS Publications
Heroin is a highly abused opioid and incurs a significant detriment to society worldwide. In
an effort to expand the limited pharmacotherapy options for opioid use disorders, a heroin …

Effectiveness of secondary prevention and treatment interventions for crack-cocaine abuse: a comprehensive narrative overview of English-language studies

B Fischer, P Blanken, D Da Silveira, A Gallassi… - International Journal of …, 2015 - Elsevier
There are an estimated several million crack-cocaine users globally; use is highest in the
Americas. Most crack users are socio-economically marginalized (eg, homeless), and …

Nanoparticle delivery systems for substance use disorder

V Kasina, RJ Mownn, R Bahal, GC Sartor - Neuropsychopharmacology, 2022 - nature.com
Innovative breakthroughs in nanotechnology are having a substantial impact in healthcare,
especially for brain diseases where effective therapeutic delivery systems are desperately …