Philosophers defined the eye as a window to the soul long before scientists addressed this
cliché to determine its scientific basis and clinical relevance. Anatomically and …

Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …

Age-related macular degeneration is the leading cause of irreversible visual dysfunction in
individuals over 65 in Western Society. Patients with AMD are classified as having early …

Blindness affects 60 million people worldwide. The leading causes of irreversible blindness
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …

Age is a common risk factor for Alzheimer's disease (AD) and age-related macular
degeneration (AMD). Because of the increasing age of the population, these two age-related …

Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease
that shares several clinical and pathological features with Alzheimer's disease (AD) …

Alzheimer's disease (AD) is the most common form of dementia affecting the growing aging
population today, with prevalence expected to rise over the next 35 years. Clinically, patients …

purpose. To compare the temporal and spatial expression patterns of amyloid precursor
protein (APP), amyloid-β deposits, inflammatory chemokines, and apoptosis in the retina of a …

Oxidative stress is closely linked to the pathogenesis of neurodegeneration. Soluble amyloid
β (Aβ) oligomers cause cognitive impairment and synaptic dysfunction in Alzheimer disease …

Aging-associated neurodegenerative diseases significantly influence the quality of life of
affected individuals. Genetic approaches, combined with genomic technology, have …