The oncogenic epithelial–mesenchymal transition (EMT) contributes to tumor progression in
various context-dependent ways, including increased metastatic potential, expansion of …

Intestinal immunity and homeostasis are maintained through the regulation of cytokine
trafficking, microbiota, necrosis and apoptosis. Intestinal immunity and homeostasis …

Autophagy has been proposed to promote cell death during lumen formation in three-
dimensional mammary epithelial acini because numerous autophagic vacuoles are …

Integrin-mediated attachment of epithelial cells to extracellular matrix (ECM) is crucial for
proper growth and survival. Although detachment leads to apoptosis, termed anoikis, recent …

Normal cells require adhesion to extracellular matrix for survival. Cell detachment causes a
drastic increase in reactive oxygen species (ROS) that promotes anoikis. In the present …

Chronic inflammation and colorectal cancer are closely linked. Although the overall
mechanisms of inflammation-associated gastrointestinal carcinogenesis are complex, it is …

Autophagy is a cellular degradation process integral for promoting cellular adaptation during
metabolic stress while also functioning as a cellular homeostatic mechanism. Mounting …

The consumption of dietary fish oil may prove to be an effective adjuvant therapy in colon
cancer. Therefore, it is both appropriate and timely to determine precisely how n-3 …

The prostate epithelial lineage hierarchy remains inadequately defined. Recent lineage-
tracing studies have implied the existence of prostate luminal epithelial progenitors with …

Chemokine receptors are essential mediators of the metastatic spread in various cancer
types; however their precise function in the development of secondary tumors remains …