Background Alpha-1 antitrypsin deficiency (AATD) is a rare hereditary condition that leads to
decreased circulating alpha-1 antitrypsin (AAT) levels, significantly increasing the risk of …

Based on the fact that oligosaccharides encode biological information, the biorecognition
between lectinised drug delivery systems and glycosylated structures in the intestine can be …

Promising improvements in the field of transcript therapeutics have clearly enhanced the
potential of mRNA as a new pillar for protein replacement therapies. Synthetic mRNAs are …

Chronic hepatitis B virus (HBV) infection is one of the leading causes of liver cirrhosis and
hepatocellular carcinoma (HCC). Current treatment strategies of HBV infection including the …

Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of
animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular …

Genetic modification therapy is a promising therapeutic strategy for many diseases of the
lung intractable to other treatments. Lung gene therapy has been the subject of numerous …

This handbook (55 chapters) provides a comprehensive roadmap of basic research in
nanomedicine as well as clinical applications. However, unlike other texts in nanomedicine …

Alpha-1 antitrypsin (AAT) deficiency, characterized by low plasma levels of the serine
protease inhibitor AAT, is associated with emphysema secondary to insufficient protection of …

The present study contributes to clarify the mechanism underlying the high efficacy of
hepatocyte gene transfer mediated by hydrodynamic injection. Gene transfer experiments …

To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle
must be able to deliver genes to the appropriate tissues and cells in the body in a specific as …